Journal article
An Outbreak of Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae in an Intensive Care Unit of a Major Teaching Hospital in Wenzhou, China
Y Zhao, X Zhang, VVL Torres, H Liu, A Rocker, Y Zhang, J Wang, L Chen, W Bi, J Lin, RA Strugnell, S Zhang, T Lithgow, T Zhou, J Cao
Frontiers in Public Health | FRONTIERS MEDIA SA | Published : 2019
Abstract
Carbapenem-resistant, hypervirulent Klebsiella pneumoniae (CR-hvKP) has recently emerged as a significant threat to public health. In this study, 29 K. pneumoniae isolates were isolated from eight patients admitted to the intensive care unit (ICU) of a comprehensive teaching hospital located in China from March 2017 to January 2018. Clinical information of patients was the basis for the further analyses of the isolates including antimicrobial susceptibility tests, identification of antibiotic resistance and virulence gene determinants, multilocus sequence typing (MLST), XbaI-macrorestriction by pulsed-field gel electrophoresis (PFGE). Selected isolates representing distinct resistance profil..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by research grants from the National Natural Science Foundation of China (No. 81741059); Program Grant 1092262 from the National Health and Medical Research Council of Australia (NHMRC); and by the Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents (No. [2012]241).